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MRI Forum: Feridex/endorem and bone MRI
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marta lola

Wed. 15 Apr.09,
12:11
Feridex/endorem and bone MRI
I would like to label cells with a paramagnetic particle to see it in vivo by MRI after implantation inside a bone defect.
I am thinking on feridex/endoderm, it has contrast effect T2, predominantly negative enhacement.
Does anybody know something about this?
Will I be able to see this kind of signal by MRI? White or blak?
Thanks a lot.
Elena Brown

Fri. 22 May.09,
20:48
 Some experiments with superparamagnetic contrast agents such as Feridex/Endorem with labeled cells showed a black appearance on T2 weighted sequences, which was easy to see. The less dominant T1 effect, bright on T1 weighted images was more subtle. (I found this also interesting http://www.nature.com/nm/journal/v7/n11/full/nm1101-1241.html and the article 'MR and iron magnetic nanoparticles. Imaging opportunities in preclinical and translational research' on http://www.tumorionline.it/cerca.php )
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