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Brain imaging, magnetic resonance imaging of the head or skull, cranial magnetic resonance tomography (MRT), neurological MRI - they describe all the same radiological imaging technique for medical diagnostic.
Magnetic resonance imaging of the human brain includes the anatomic description and the detection of lesions. Special techniques like diffusion weighted imaging, functional magnetic resonance imaging ( fMRI) and spectroscopy provide also information about the function and chemical metabolites of the brain.
MRI provides detailed pictures of brain and nerve tissues in multiple planes without obstruction by overlying bones. Brain MRI is the procedure of choice for most brain disorders. It provides clear images of the brainstem and posterior brain, which are difficult to view on a CT scan. It is also useful for the diagnosis of demyelinating disorders (disorders such as multiple sclerosis (MS) that cause destruction of the myelin sheath of the nerve).
With this noninvasive procedure also the evaluation of blood flow and the flow of cerebrospinal fluid (CSF) is possible. Different MRA methods, also without contrast agents can show a venous or arterial angiogram. MRI can distinguish tumors, inflammatory lesions, and other pathologies from the normal brain anatomy. However, MRI scans are also used instead other methods to avoid the dangers of interventional procedures like angiography (DSA - digital subtraction angiography) as well as of repeated exposure to radiation as required for computed tomography (CT) and other X-ray examinations.
A ( birdcage) bird cage coil achieves uniform excitation and reception and is commonly used to study the brain. Usually a brain MRI procedure includes FLAIR, T2 weighted and T1 weighted sequences in two or three planes. See also Fetal MRI, Fluid Attenuation Inversion Recovery ( FLAIR), Perfusion Imaging and High Field MRI. See also Arterial Spin Labeling. | | | | | | | | | | | | | Further Reading: | | Basics:
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MRI Reveals Significant Brain Abnormalities Post-COVID Monday, 21 November 2022 by neurosciencenews.com | | |
Combining genetics and brain MRI can aid in predicting chances of Alzheimer's disease Wednesday, 29 June 2022 by www.sciencedaily.com | | |
Roundup: How Even Mild COVID Can Affect the Brain; This Many Daily Steps Improves Longevity; and More Friday, 11 March 2022 by baptisthealth.net | | |
A low-cost and shielding-free ultra-low-field brain MRI scanner Tuesday, 14 December 2021 by www.nature.com | | |
Large International Study Reveals Spectrum of COVID-19 Brain Complications Tuesday, 9 November 2021 by www.itnonline.com | | |
Brain MRI-Based Subtypes of MS Predict Disability Progression, Treatment Response Thursday, 13 May 2021 by www.neurologyadvisor.com | | |
New MRI method improves detection of disease changes in the brain's network Thursday, 11 June 2020 by www.compute.dtu.dk | | |
New NeuroCOVID Classification System Uses MRI to Categorize Patients Friday, 12 June 2020 by www.diagnosticimaging.com | | |
New MRI technique can 'see' molecular changes in the brain Thursday, 5 September 2019 by medicalxpress.com | | |
Talking therapy or medication for depression: Brain scan may help suggest better treatment Monday, 27 March 2017 by www.newsnation.in | | |
MRI identifies brain abnormalities in chronic fatigue syndrome patients Wednesday, 29 October 2014 by www.eurekalert.org | | |
MRIs Useful in Tracking Depression in MS Patients Tuesday, 1 July 2014 by www.hcplive.com | | |
Contrast agent linked with brain abnormalities on MRI Tuesday, 17 December 2013 by www.sciencecodex.com | | |
MRIs Reveal Signs of Brain Injuries Not Seen in CT Scans Tuesday, 18 December 2012 by www.sciencedaily.com | | |
Iron Deposits in the Brain May Be Early Indicator of MS Wednesday, 13 November 2013 by www.healthline.com | | |
Migraine Sufferers Have Thicker Brain Cortex Tuesday, 20 November 2007 by www.medicalnewstoday.com |
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Cardiovascular MR imaging includes the complete anatomical display of the heart with CINE imaging of all phases of the heartbeat. Ultrafast techniques make breath hold three-dimensional coverage of the heart in different cardiac axes feasible. Cardiac MRI provides reliable anatomical and functional assessment of the heart and evaluation of myocardial viability and coronary artery disease by a noninvasive diagnostic imaging technique.
Cardiovascular MRI offers potential advantages over radioisotopic techniques because it provides superior spatial resolution, does not use ionizing radiation, has no imaging orientations constraints and contrast resolution better than echocardiography. It also offers direct visualization and characterization of atherosclerotic plaques and diseased vessel walls and surrounding tissues in cardiovascular research.
MRI perfusion approaches measure the alteration of regional myocardial magnetic properties after the intravenous injection of contrast agents and assess the extent of injury after a myocardial infarction and the presence of myocardial viability with a technique based on late enhancement. Extracellular MRI contrast agents, like Gd-DTPA, accumulate only in irreversibly damaged myocardium after a time period of at least 10 minutes.
This type of patients may also have an implanted cardiac stent, bypass or a cardiac pacemaker and special caution should be observed on the MRI safety and the contraindications. While a number of coronary stents have been tested and reported to be MRI compatible, coronary stents must be assessed on an individual basis, with the medical team weighing the risks and benefits of the MRI procedure.
Cardiac MRI overview:
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Calculation of ventricular volume, myocardial mass and wall thickness
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Description of a stenosis or aneurysma
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Anatomical display of the heart, vessels and the surrounding tissue
Cardiovascular MRI has become one of the most effective noninvasive imaging techniques for almost all groups of heart and vascular disease. | | | | | | • View the DATABASE results for 'Cardiovascular Imaging' (18).
| | | • View the NEWS results for 'Cardiovascular Imaging' (6).
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A large network of interconnecting blood vessels at the base of the brain that when visualized resembles a circle, the arteries effectively act as anastomoses for each other. This means that if any one of the communicating arteries becomes blocked, blood can flow from another part of the circle to ensure that blood flow is not compromised.
The circle of Willis is formed by both the internal carotid arteries, entering the brain from each side and the basilar artery, entering posteriorly. The connection of the vertebral arteries forms the basilar artery. The basilar artery divides into the right and left posterior cerebral arteries.
The internal carotid arteries trifurcate into the anterior cerebral artery, middle cerebral artery, and posterior communicating artery.
The two anterior cerebral arteries are joined together anteriorly by the anterior communicating artery. The posterior communicating arteries join the posterior cerebral arteries, completing the circle of Willis. The time of flight angiography MRI technique allows imaging of the circle of Willis without the need of a contrast medium (best results with high field MRI). A cerebrovasular contrast enhanced magnetic resonance angiography ( MRA) depicts the circle of Willis in addition to the vessels of the neck (carotid and vertebral arteries) with one bolus injection of a contrast agent.
For Ultrasound Imaging (USI) see Cerebrovascular Ultrasonography at Medical-Ultrasound-Imaging.com. | | | | | | • View the DATABASE results for 'Circle of Willis' (5).
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Contrast agents are chemical substances introduced to the anatomical or functional region being imaged, to increase the differences between different tissues or between normal and abnormal tissue, by altering the relaxation times. MRI contrast agents are classified by the different changes in relaxation times after their injection.
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Negative contrast agents (appearing predominantly dark on MRI) are small particulate aggregates often termed superparamagnetic iron oxide ( SPIO). These agents produce predominantly spin spin relaxation effects (local field inhomogeneities), which results in shorter T1 and T2 relaxation times.
SPIO's and ultrasmall superparamagnetic iron oxides ( USPIO) usually consist of a crystalline iron oxide core containing thousands of iron atoms and a shell of polymer, dextran, polyethyleneglycol, and produce very high T2 relaxivities. USPIOs smaller than 300 nm cause a substantial T1 relaxation. T2 weighted effects are predominant.
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A special group of negative contrast agents (appearing dark on MRI) are perfluorocarbons ( perfluorochemicals), because their presence excludes the hydrogen atoms responsible for the signal in MR imaging.
The design objectives for the next generation of MR contrast agents will likely focus on prolonging intravascular retention, improving tissue targeting, and accessing new contrast mechanisms. Macromolecular paramagnetic contrast agents are being tested worldwide. Preclinical data shows that these agents demonstrate great promise for improving the quality of MR angiography, and in quantificating capillary permeability and myocardial perfusion.
Ultrasmall superparamagnetic iron oxide ( USPIO) particles have been evaluated in multicenter clinical trials for lymph node MR imaging and MR angiography, with the clinical impact under discussion. In addition, a wide variety of vector and carrier molecules, including antibodies, peptides, proteins, polysaccharides, liposomes, and cells have been developed to deliver magnetic labels to specific sites. Technical advances in MR imaging will further increase the efficacy and necessity of tissue-specific MRI contrast agents.
See also Adverse Reaction and Nephrogenic Systemic Fibrosis.
See also the related poll result: ' The development of contrast agents in MRI is' | | | | | | | | | | | • View the DATABASE results for 'Contrast Agents' (122).
| | | • View the NEWS results for 'Contrast Agents' (25).
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Brain imaging method may aid mild traumatic brain injury diagnosis Tuesday, 16 January 2024 by parkinsonsnewstoday.com | | |
A Targeted Multi-Crystalline Manganese Oxide as a Tumor-Selective Nano-Sized MRI Contrast Agent for Early and Accurate Diagnosis of Tumors Thursday, 18 January 2024 by www.dovepress.com | | |
FDA Approves Gadopiclenol for Contrast-Enhanced Magnetic Resonance Imaging Tuesday, 27 September 2022 by www.pharmacytimes.com | | |
How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol Saturday, 5 February 2022 by www.ncbi.nlm.nih.gov | | |
Estimation of Contrast Agent Concentration in DCE-MRI Using 2 Flip Angles Tuesday, 11 January 2022 by pubmed.ncbi.nlm.nih.gov | | |
Manganese enhanced MRI provides more accurate details of heart function after a heart attack Tuesday, 11 May 2021 by www.news-medical.net | | |
Gadopiclenol: positive results for Phase III clinical trials Monday, 29 March 2021 by www.pharmiweb.co | | |
Gadolinium-Based Contrast Agents Hypersensitivity: A Case Series Friday, 4 December 2020 by www.dovepress.com | | |
Polysaccharide-Core Contrast Agent as Gadolinium Alternative for Vascular MR Monday, 8 March 2021 by www.diagnosticimaging.com | | |
Water-based non-toxic MRI contrast agents Monday, 11 May 2020 by chemistrycommunity.nature.com | | |
New method to detect early-stage cancer identified by Georgia State, Emory research team Friday, 7 February 2020 by www.eurekalert.org | | |
Researchers Brighten Path for Creating New Type of MRI Contrast Agent Friday, 7 February 2020 by www.newswise.com | | |
Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents Wednesday, 15 November 2017 by www.eurekalert.org | | |
Sodium MRI May Show Biomarker for Migraine Friday, 1 December 2017 by psychcentral.com | | |
A natural boost for MRI scans Monday, 21 October 2013 by www.eurekalert.org | | |
For MRI, time is of the essence A new generation of contrast agents could make for faster and more accurate imaging Tuesday, 28 June 2011 by scienceline.org |
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| | | Searchterm 'Angiography' was also found in the following services: | | | | |
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Contrast enhanced MRI is a commonly used procedure in magnetic resonance imaging. The need to more accurately characterize different types of lesions and to detect all malignant lesions is the main reason for the use of intravenous contrast agents.
Some methods are available to improve the contrast of different tissues. The focus of dynamic contrast enhanced MRI (DCE-MRI) is on contrast kinetics with demands for spatial resolution dependent on the application. DCE- MR imaging is used for diagnosis of cancer (see also liver imaging, abdominal imaging, breast MRI, dynamic scanning) as well as for diagnosis of cardiac infarction (see perfusion imaging, cardiac MRI). Quantitative DCE-MRI requires special data acquisition techniques and analysis software.
Contrast enhanced magnetic resonance angiography (CE-MRA) allows the visualization of vessels and the temporal resolution provides a separation of arteries and veins. These methods share the need for acquisition methods with high temporal and spatial resolution.
Double contrast administration (combined contrast enhanced (CCE) MRI) uses two contrast agents with complementary mechanisms e.g., superparamagnetic iron oxide to darken the background liver and gadolinium to brighten the vessels. A variety of different categories of contrast agents are currently available for clinical use.
Reasons for the use of contrast agents in MRI scans are:
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Relaxation characteristics of normal and pathologic tissues are not always different enough to produce obvious differences in signal intensity.
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Pathology that is sometimes occult on unenhanced images becomes obvious in the presence of contrast.
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Enhancement significantly increases MRI sensitivity.
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In addition to improving delineation between normal and abnormal tissues, the pattern of contrast enhancement can improve diagnostic specificity by facilitating characterization of the lesion(s) in question.
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Contrast can yield physiologic and functional information in addition to lesion delineation.
Common Indications:
Brain MRI : Preoperative/pretreatment evaluation and postoperative evaluation of brain tumor therapy, CNS infections, noninfectious inflammatory disease and meningeal disease.
Spine MRI : Infection/inflammatory disease, primary tumors, drop metastases, initial evaluation of syrinx, postoperative evaluation of the lumbar spine: disk vs. scar.
Breast MRI : Detection of breast cancer in case of dense breasts, implants, malignant lymph nodes, or scarring after treatment for breast cancer, diagnosis of a suspicious breast lesion in order to avoid biopsy.
For Ultrasound Imaging (USI) see Contrast Enhanced Ultrasound at Medical-Ultrasound-Imaging.com.
See also Blood Pool Agents, Myocardial Late Enhancement, Cardiovascular Imaging, Contrast Enhanced MR Venography, Contrast Resolution, Dynamic Scanning, Lung Imaging, Hepatobiliary Contrast Agents, Contrast Medium and MRI Guided Biopsy. | | | | | | | | | | | • View the DATABASE results for 'Contrast Enhanced MRI' (14).
| | | • View the NEWS results for 'Contrast Enhanced MRI' (8).
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News & More:
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FDA Approves Gadopiclenol for Contrast-Enhanced Magnetic Resonance Imaging Tuesday, 27 September 2022 by www.pharmacytimes.com | | |
Effect of gadolinium-based contrast agent on breast diffusion-tensor imaging Thursday, 6 August 2020 by www.eurekalert.org | | |
Artificial Intelligence Processes Provide Solutions to Gadolinium Retention Concerns Thursday, 30 January 2020 by www.itnonline.com | | |
Accuracy of Unenhanced MRI in the Detection of New Brain Lesions in Multiple Sclerosis Tuesday, 12 March 2019 by pubs.rsna.org | | |
The Effects of Breathing Motion on DCE-MRI Images: Phantom Studies Simulating Respiratory Motion to Compare CAIPIRINHA-VIBE, Radial-VIBE, and Conventional VIBE Tuesday, 7 February 2017 by www.kjronline.org | | |
Novel Imaging Technique Improves Prostate Cancer Detection Tuesday, 6 January 2015 by health.ucsd.edu | | |
New oxygen-enhanced MRI scan 'helps identify most dangerous tumours' Thursday, 10 December 2015 by www.dailymail.co.uk | | |
All-organic MRI Contrast Agent Tested In Mice Monday, 24 September 2012 by cen.acs.org | | |
A groundbreaking new graphene-based MRI contrast agent Friday, 8 June 2012 by www.nanowerk.com |
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