(ADC) A diffusion coefficient to differentiate T2 shine through effects or artifacts from real ischemic lesions. In the human brain, water diffusion is a three-dimensional process that is not truly random because the diffusional motion of water is impeded by natural barriers. These barriers are cell membranes, myelin sheaths, white matter fiber tracts, and protein molecules.
The apparent water diffusion coefficients can be calculated by acquiring two or more images with a different gradient duration and amplitude (b-values). The contrast in the ADC map depends on the spatially distributed diffusion coefficient of the acquired tissues and does not contain T1 and T2* values.
The increased sensitivity of diffusion-weighted MRI in detecting acute ischemia is thought to be the result of the water shift intracellularly restricting motion of water protons (cytotoxic edema), whereas the conventional T2 weighted images show signal alteration mostly as a result of vasogenic edema.
The reduced ADC value also could be the result of decreased temperature in the nonperfused tissues, loss of brain pulsations leading to a decrease in apparent proton motion, increased tissue osmolality associated with ischemia, or a combination of these factors. The lower ADC measurements seen with early ischemia, have not been fully established, however, a lower apparent ADC is a sensitive indicator of early ischemic brain at a stage when ischemic tissue remains potentially salvageable.

See also Diffusion Weighted Imaging and Diffusion Tensor Tractography.

(ASSET) ASSET is a parallel imaging technique of the SENSE type (image domain reconstruction).
Each coil element is sensitivity encoded and the covered spatial zone is mapped. By reducing the field of view in the phase encoding gradient direction the scan time decreases, but this images of each coil element contain foldover artifacts. The sensitivity profiles of the elements are used to calculate unfolded images.

See also Sensitivity Encoding, Generalized Autocalibrating Partially Parallel Acquisition.

See Artifact

A strategy for incrementing the position of the k-space trajectory of an echo planar imaging (EPI) pulse sequence.
Echo planar imaging (EPI) uses a constant gradient amplitude in one direction. This, combined with an oscillating gradient system in the frequency encoding direction, produces a zigzag trajectory in k-space. In the blipped phase encoding variant of EPI, the k-space position in the phase encoded direction is incremented by gradient 'blips' of the appropriate area. These, when timed to occur during the reversals of the read-out gradient, produce a rectilinear path in k-space.
The artifacts in an EPI image can arise from both hardware and sample imperfections. These are most easily understandable from examination of the k-space trajectory involved, which is either a zigzag form (when using a constant phase encoding gradient) or a rastered zigzag (when the phase encoding is performed with small gradients at the end of each scan line, so-called 'blipped' EPI).

A bolus is a rapid infusion of high dose contrast agent. Dynamic and accumulation phase imaging can be performed after bolus injection. Since the transit time of the bolus through the tissue is only a few seconds, high temporal resolution imaging can be required to obtain sequential images during the wash in and wash out of the contrast material and, therefore, resolve the first pass of the tracer.
For the same injected dose of contrast agent the injection rate (and, consequently, the total injected volume) modifies the bolus peak profile. Increasing the injection rate produces a sharpening of the peak (Cmax increase, Tmax decrease, peak length decrease). At a low injection rate, the first pass presents a plateau form. Substantial changes in the gadolinium concentrations during signal acquisition induce artifacts. Furthermore, the haemodynamic parameters (cardiac output, blood pressure) influence the bolus profile. The characteristics of gadolinium agents are favorable in the early bolus phase, whereas the advantages of large complexes (e.g. blood pool agents) and ultrasmall superparamagnetic iron oxide (USPIO) are most evident in the distribution phase.