Sinerem® is the brand name (same as Combidex®) for an ultrasmall superparamagnetic iron oxide (USPIO) to detect metastatic disease in lymph nodes. Metastatic nodes show less uptake of this MRI contrast agent, which results in less signal decrease and allows the differentiation of normal lymph nodes from normal-sized, metastatic nodes.
Lymph node imaging with Sinerem® is performed 24 to 36 hours after slow infusion. Normal lymph nodes turn black post contrast, namely on T2* weighted images. Metastatic lymph nodes remain unchanged in signal intensity.
Indication and Diseases: Cancer, Imaging for diagnosis, Lymphatic disorders.
See Ferumoxtran, and Classifications, Characteristics, etc.

Guerbet decided in 2007 to withdraw its Marketing Authorisation Application (MAA) for Sinerem.

Artirem®, the arthrography-specific contrast agent for MRI is a dilute form of Dotarem® with a less concentration of Gd (1:200). Artirem® has to be injected directly into the joints for better visualization and delimitation, of the ligament and tendon structures in particular.

[B₁] A conventional symbol for the radio frequency field strength (another symbol historically used, is H1). In MRI, B1 labels the field produced by the radio frequency coil.
The B1 field is often conceived of two vectors rotating in opposite directions, usually in a plane transverse to B0. At the Larmor frequency, the vector rotating in the same direction as the precessing spins will interact strongly with the spins.

An iron-based contrast agent with large molecular size, which prevents diffusion into body tissues and will be developed for MR imaging of the liver (taken up by macrophages), tumor microvasculature and microvessel permeability. The blood half live of the particles with 11-20 nm diameter is 3-4 hours.
At this time the development of Clariscanâ„¢ is discontinued.

See also NC100150 Injection and Ultrasmall Superparamagnetic Iron Oxide.

A coil consists of one or more loops of conductive wire, looped around the core of the coil. Coils are part of the hardware of MRI machines and are used to create a magnetic field or to detect a changing magnetic field by voltage induced in the wire. A coil is usually a physically small antenna.
The perfect coil produces a uniform magnetic field without significant radiation.
Different types of MRI coils are used in MR systems:
Gradient coils are used to produce controlled variations in the main magnetic field (B0) to provide spatial localization of the signals and to apply reversal pulses in some imaging techniques.
MR imaging radio frequency coils to receive and/or transmit the RF signal.
Shim coils provide auxiliary magnetic fields in order to compensate for inhomogeneities in the main magnetic field of the MRI machine.

See also Gradient Coil, Radio Frequency Coil, Hardware and Coil Loading.

See also the related POLL result: '3rd party coils are better than the original manufacturer coils'