Process by which regions of tissue are selectively sampled to produce spectra from defined volumes in space. These methods may be employed to sample a single region in space (single voxel method) or multiple regions simultaneously (multivoxel methods). The spatial selectivity can be achieved by a variety of methods including surface coils, surface coils in conjunction with RF gradient methods, or RF pulses in combination with switched magnetic field gradients, for example, volume-selective excitation. An indirect method of achieving spatial selectivity is the destruction of coherence of the magnetization in regions that lie outside the region of interest. A variety of spatial encoding schemes have been employed for multivoxel localization. See Chemical shift imaging.

A spectral line is a particular distinct frequency or narrow band of a frequency set. The resonance of this frequency occurs corresponding to a particular chemical shift. Theoretically, the frequency of a pure sine wave displays sharp spectral lines at the point of Larmor frequency. In reality, the spectral lines spread into a blurred peak, caused by field inhomogeneities and spin-spin effect.

For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different spectroscopic imaging techniques available.
A short listing of the most frequent variations:

Edward Purcell and Felix Bloch discovered the basic of spectroscopy in 1946 (see MRI History). Nuclear magnetic resonance spectroscopy (NMR Spectroscopy or MRS) is an analytical tool, based on nuclei that have a spin (nuclei with an odd number of neutrons and/or protons) like 1H, 13C, 17O, 19F, 31P etc.
Through nuclear magnetic principles as precession, chemical shift, spin spin coupling etc., the analysis of the content, purity, and molecular structure of a sample is possible. The spectrum produced by this process contains a number of peaks; the highs and the positions of these peaks allow the exact analysis. Unknown compounds can be matched against spectral libraries. Even very complex organic compounds as enzymes and proteins can be determined. For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different techniques available.
See Spectroscopic Imaging Techniques.

(SE) The Reappearance of the MR signal after the FID has apparently died away, as a result of the effective reversal (rephasing) of the dephasing spins by techniques such as specific RF pulse sequences or pairs of field gradient pulses, applied in time shorter than or on the order of T2. Proper selection of the TE time of the pulse sequence can help to control the amount of T1 or T2 contrast present in the image. Pulse sequences of the spin echo type, usually employs a 90° pulse, followed by one or more 180° pulses to eliminate field inhomogeneity and chemical shift effects at the echo. Caused by this 180° refocusing pulse, spin echo or fast spin echo (FSE, TSE) sequences are more robust against e.g. susceptibility artifacts than sequences of the gradient echo type.