(MRS / MRSI - Magnetic Resonance Spectroscopic Imaging) A method using the NMR phenomenon to identify the chemical state of various elements without destroying the sample. MRS therefore provides information about the chemical composition of the tissues and the changes in chemical composition, which may occur with disease processes.
Although MRS is primarily employed as a research tool and has yet to achieve widespread acceptance in routine clinical practice, there is a growing realization that a noninvasive technique, which monitors disease biochemistry can provide important new information for the clinician.
The underlying principle of MRS is that atomic nuclei are surrounded by a cloud of electrons, which very slightly shield the nucleus from any external magnetic field. As the structure of the electron cloud is specific to an individual molecule or compound, then the magnitude of this screening effect is also a characteristic of the chemical environment of individual nuclei.
In view of the fact that the resonant frequency is proportional to the magnetic field that it experiences, it follows that the resonant frequency will be determined not only by the external applied field, but also by the small field shift generated by the electron cloud. This shift in frequency is called the chemical shift (see also Chemical Shift). It should be noted that chemical shift is a very small effect, usually expressed in ppm of the main frequency. In order to resolve the different chemical species, it is therefore necessary to achieve very high levels of homogeneity of the main magnetic field B0. Spectra from humans usually require shimming the magnet to approximately one part in 100. High resolution spectra of liquid samples demand a homogeneity of about one part in 1000.
In addition to the effects of factors such as relaxation times that can affect the NMR signal, as seen in magnetic resonance imaging, effects such as J-modulation or the transfer of magnetization after selective excitation of particular spectral lines can affect the relative strengths of spectral lines.
In the context of human MRS, two nuclei are of particular interest - H-1 and P-31. (PMRS - Proton Magnetic Resonance Spectroscopy) PMRS is mainly employed in studies of the brain where prominent peaks arise from NAA, choline containing compounds, creatine and creatine phosphate, myo-inositol and, if present, lactate; phosphorus 31 MR spectroscopy detects compounds involved in energy metabolism (creatine phosphate, adenosine triphosphate and inorganic phosphate) and certain compounds related to membrane synthesis and degradation. The frequencies of certain lines may also be affected by factors such as the local pH. It is also possible to determine intracellular pH because the inorganic phosphate peak position is pH sensitive.
If the field is uniform over the volume of the sample, "similar" nuclei will contribute a particular frequency component to the detected response signal irrespective of their individual positions in the sample. Since nuclei of different elements resonate at different frequencies, each element in the sample contributes a different frequency component. A chemical analysis can then be conducted by analyzing the MR response signal into its frequency components.

See also Spectroscopy.

(SAR) The Specific Absorption Rate is defined as the RF power absorbed per unit of mass of an object, and is measured in watts per kilogram (W/kg).
The SAR describes the potential for heating of the patient's tissue due to the application of the RF energy necessary to produce the MR signal. Inhomogeneity of the RF field leads to a local exposure where most of the absorbed energy is applied to one body region rather than the entire person, leading to the concept of a local SAR. Hot spots may occur in the exposed tissue, to avoid or at least minimize effects of such theoretical complications, the frequency and the power of the radio frequency irradiation should be kept at the lowest possible level. Averaging over the whole body leads to the global SAR.
It increases with field strength, radio frequency power and duty cycle, transmitter-coil type and body size. The doubling of the field strength from 1.5 Tesla (1.5T) to 3 Tesla (3T) leads to a quadrupling of SAR. In high and ultrahigh fields, some of the multiple echo, multiple-slice pulse sequences may create a higher SAR than recommended by the agencies. SAR can be reduced by lower flip angle and longer repetition times, which could potentially affect image contrast.
Normally no threatening increase in temperature could be shown. Even in high magnetic fields, the local temperature increases not more than 1°C. 2.1°C is the highest measured increase in skin temperature. Eddy currents may heat up implants and thus may cause local heating.

FDA SAR limits:

IEC (International Electrotechnical Commission) SAR limits of some European countries:
All limits are averaged over 6 minutes. (For more details: IEC 60601-2-33 (2002))

In most countries standard MRI systems are limited to a maximum SAR of 4 W/kg, so most scanning in level II is impossible.
For Level I, in addition to routine monitoring, particular caution must be exercised for patients who are sensitive to temperature increases or to RF energy.
For Japan different SAR limits are valid.