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NitroxidesInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.
 
Nitroxide radicals (or nitroxyl spin labels) are stable organic compounds with theoretical potential for use as a paramagnetic MRI contrast agent. Similar to gadolinium they have an unpaired electron, a property that provides enhancement in T1 based MRI, and a comparable pharmacokinetic. Depending on their structure and chemical bonding, different nitroxides formula may have the potential for use as cardiovascular imaging agents, to enhance the MR imaging on joints (e.g., dendrimer-linked nitroxides have a strong affinity for cartilage), to evaluate brain tumors and infarction, and as a contrast enhancement agent of body/abdominal NMR imaging. Nitroxides are rapidly enzymatically reduced in tissues to products that do not enhance the NMR signal, which can be a problem for MR imaging. In animal experiments with EPRI (electron paramagnetic resonance imaging), tissue redox studies show differences between tumors and normal tissues, which reflect their respective redox status consistent with the reduction/clearance of nitroxides.
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Electron Paramagnetic Resonance for Small Animal Imaging Applications
   by pet.radiology.uiowa.edu    
MRI Resources 
Fluorescence - Calculation - - Education - Liver Imaging - NMR
 
Partial Fourier Technique
 
The partial Fourier technique is a modification of the Fourier transformation imaging method used in MRI in which the symmetry of the raw data in k-space is used to reduce the data acquisition time by acquiring only a part of k-space data.
The symmetry in k-space is a basic property of Fourier transformation and is called Hermitian symmetry. Thus, for the case of a real valued function g, the data on one half of k-space can be used to generate the data on the other half.
Utilization of this symmetry to reduce the acquisition time depends on whether the MRI problem obeys the assumption made above, i.e. that the function being characterized is real.
The function imaged in MRI is the distribution of transverse magnetization Mxy, which is a vector quantity having a magnitude, and a direction in the transverse plane. A convenient mathematical notation is to use a complex number to denote a vector quantity such as the transverse magnetization, by assigning the x'-component of the magnetization to the real part of the number and the y'-component to the imaginary part. (Sometimes, this mathematical convenience is stretched somewhat, and the magnetization is described as having a real component and an imaginary component. Physically, the x' and y' components of Mxy are equally 'real' in the tangible sense.)
Thus, from the known symmetry properties for the Fourier transformation of a real valued function, if the transverse magnetization is entirely in the x'-component (i.e. the y'-component is zero), then an image can be formed from the data for only half of k-space (ignoring the effects of the imaging gradients, e.g. the readout- and phase encoding gradients).
The conditions under which Hermitian symmetry holds and the corrections that must be applied when the assumption is not strictly obeyed must be considered.
There are a variety of factors that can change the phase of the transverse magnetization:
Off resonance (e.g. chemical shift and magnetic field inhomogeneity cause local phase shifts in gradient echo pulse sequences. This is less of a problem in spin echo pulse sequences.
Flow and motion in the presence of gradients also cause phase shifts.
Effects of the radio frequency RF pulses can also cause phase shifts in the image, especially when different coils are used to transmit and receive.
Only, if one can assume that the phase shifts are slowly varying across the object (i.e. not completely independent in each pixel) significant benefits can still be obtained. To avoid problems due to slowly varying phase shifts in the object, more than one half of k-space must be covered. Thus, both sides of k-space are measured in a low spatial frequency range while at higher frequencies they are measured only on one side. The fully sampled low frequency portion is used to characterize (and correct for) the slowly varying phase shifts.
Several reconstruction algorithms are available to achieve this. The size of the fully sampled region is dependent on the spatial frequency content of the phase shifts. The partial Fourier method can be employed to reduce the number of phase encoding values used and therefore to reduce the scan time. This method is sometimes called half-NEX, 3/4-NEX imaging, etc. (NEX/NSA). The scan time reduction comes at the expense of signal to noise ratio (SNR).
Partial k-space coverage is also useable in the readout direction. To accomplish this, the dephasing gradient in the readout direction is reduced, and the duration of the readout gradient and the data acquisition window are shortened.
This is often used in gradient echo imaging to reduce the echo time (TE). The benefit is at the expense in SNR, although this may be partly offset by the reduced echo time. Partial Fourier imaging should not be used when phase information is eligible, as in phase contrast angiography.

See also acronyms for 'partial Fourier techniques' from different manufacturers.
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MRI Resources 
Online Books - Education - Spine MRI - MRA - Stimulator pool - Blood Flow Imaging
 
Upperton LimitedMRI Resource Directory:
 - Developers -
 
www.upperton.com/products.htm Research Project Description
Lung Imaging X-ray and MRI contrast agents for lung MRI applications.
Blood Pool Imaging MRI contrast agents for vascular and targeted imaging.

Nuclear Imaging Agents based on recombinant human albumin for nuclear imaging.
Contact Information
MAIL
Upperton Limited
Dr Richard Johnson
PO Box 6861
Nottingham, NG2 5PF
Great Britain
PHONE
+44-(0)115-945-2378
FAX
+44-(0)115-945-2378
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Further Reading:
  Basics:
Blood-Pool Imaging Using Technetium-99m-Labeled Liposomes(.pdf)
   by jnm.snmjournals.org    
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iMotion™ 1.5 Tesla MagnetInfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.MRI Resource Directory:
 - Devices -
 
www.imris.com/ The mobile intraoperative iMotion system produces real-time images used for MR guided surgery and offers functional magnetic resonance imaging, MR spectroscopy, perfusion imaging, and diffusion weighted imaging capabilities.
The iMotion 1.5 T magnet moves to the patient, gliding in and out of place as needed, without affecting surgical, anesthetic, and nursing management.

See also Intraoperative Magnetic Resonance Imaging, MR Guided Interventions.
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Mobile compact
Whole body, intra-operative head, neck volume, atlas head//neck vascular quadrature phased array, spine quadrature, C/T/L spine phased array, small joint, large joint, TMJ bilateral, shoulder phased array, extremity quadrature volume, wrist, hand quadrature, general purpose flexible, pelvis/abdomen phased array, body quadrature, phased array flexible, breast bilateral
SYNCHRONIZATION
Standard cardiac gating, ECG/peripheral, respiratory gating
PULSE SEQUENCES
SE, IR, TSE, EPI, Diffusion, Perfusion, Angiography
IMAGING MODES
Localizer, single slice, multislice, volume
Active
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MRI Resources 
Veterinary MRI - Collections - Artifacts - Service and Support - Equipment - Directories
 
Amersham plcMRI Resource Directory:
 - Manufacturers -
 
www.amersham.com [This entry is marked for removal.]

GE Medical Systems and Amersham announced in April 2004 the completion of a share exchange acquisition of Amersham Health by GE. The result of this acquisition is the new GE Healthcare, based in the UK, totally owned by General Electric (GE).

Amersham plc, was a producer of contrast imaging agents used to enhance image quality in X-ray, magnetic resonance imaging, and ultrasound procedures. It was also a leading producer of radiopharmaceuticals used in nuclear medicine imaging. Amersham Health was the firm's imaging, diagnostics, and therapeutics segment. Amersham plc was involved in biotechnology research through its Amersham Biosciences unit, which made scanners, sequencers, microarrays, industrial separations, and other research supplies.
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Further Reading:
  News & More:
Recommended Share Exchange Acquisition by General Electric Company and GE Investments, Inc. of Amersham plc
Friday, 10 October 2003   by www.evaluatepharma.com    
MRI Resources 
PACS - Contrast Agents - General - Cardiovascular Imaging - Safety Training - Devices
 
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