The France-based Guerbet Group is highly specialized in contrast media for medical imaging. Its strategic goal is to be a key player in this market. Products include Dotarem (Magnetic Resonance Imaging) and Xenetix (X-ray Imaging).

MRI Contrast Agents:

(Hb) Haemoglobin is the major endogenous oxygen-binding molecule, responsible for binding oxygen in the lung and transporting it to the tissues by means of the circulation. Haemoglobin is contained in very high concentration in the red blood cells.
Haemoglobin is an Fe chelate tightly binding one Fe ion in its II oxidation state where it carries the charge 2+ (ferrous iron). If an oxygen molecule is bound to Hb, Hb is called oxyhaemoglobin, if no oxygen molecule is bound it is called deoxyhaemoglobin. When haemoglobin is oxidized (i.e. in a haematoma), Fe2+ is transformed into Fe3+. The resulting haemoglobin is then called metoxyhaemoglobin (Hb Fe3+).
Deoxyhaemoglobin and metoxyhaemoglobin act as paramagnetic contrast agents in MR, while oxyhaemoglobin is diamagnetic. This partly explains the special appearance of an aging haematoma in MR imaging and is also the basic of the blood oxygenation level dependent contrast (BOLD) used in functional magnetic resonance imaging of the brain (fMRI).

Magnetic resonance imaging of the heart is a diagnostic MRI procedure that is useful to evaluate the structures, the function and viability of the heart and the major blood vessels.

See also Cardiac MRI, Cardiovascular Imaging, MRA, Cardiac Stent, Myocardial Late Enhancement and Coronary Angiography.

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Hitachi Medical Systems America, Inc. (HMSA), was a major provider of magnetic resonance imaging systems in the United States. Hitachi had more than 2300 installed permanent magnet MR imaging systems worldwide. As a full-line supplier of medical imaging equipment in Japan, Hitachi Medical Corporation (HMC) founded HMSA to provide a direct link to the U.S. marketplace. Altaire™ , the open MR system from Hitachi, extends the family of open MRI products.

In December 2019 Japan's Fujifilm announced the acquisition of Hitachi's diagnostic imaging business for 179 billion yen ($1.63 billion). This includes Hitachi’s CT, MRI, X-ray, and ultrasound imaging operations, also its electronic health record business. Fujifilm expects the deal to close in July 2020 subject to regulatory clearances.

MRI Scanners:

0.3T to 0.7T:
1.5T:

IMRIS® is a Canadian manufacturer of Magnetic Resonance Imaging Systems for use in neurosurgical operating rooms. The 1.5T intra-operative system, developed by IMRIS, is the only system of its kind in the world. This patented, intra-operative system, is designed so that the magnet moves over the patient for imaging (before, during and after surgery), and then is retracted to allow complete surgical access to the patient.

MRI Scanners:

1.5T: