Contrast agents are chemical substances introduced to the anatomical or functional region being imaged, to increase the differences between different tissues or between normal and abnormal tissue, by altering the relaxation times. MRI contrast agents are classified by the different changes in relaxation times after their injection.
The design objectives for the next generation of MR contrast agents will likely focus on prolonging intravascular retention, improving tissue targeting, and accessing new contrast mechanisms. Macromolecular paramagnetic contrast agents are being tested worldwide. Preclinical data shows that these agents demonstrate great promise for improving the quality of MR angiography, and in quantificating capillary permeability and myocardial perfusion.
Ultrasmall superparamagnetic iron oxide (USPIO) particles have been evaluated in multicenter clinical trials for lymph node MR imaging and MR angiography, with the clinical impact under discussion. In addition, a wide variety of vector and carrier molecules, including antibodies, peptides, proteins, polysaccharides, liposomes, and cells have been developed to deliver magnetic labels to specific sites. Technical advances in MR imaging will further increase the efficacy and necessity of tissue-specific MRI contrast agents.

See also Adverse Reaction and Nephrogenic Systemic Fibrosis.

See also the related poll result: 'The development of contrast agents in MRI is'

Short name: Gd-DTPA-PEG, generic name: Gd-DTPA-PEG polymers, chemical compound: Gadolinium DTPA polyethylene glycol, central moiety: Gd2+, relaxivity: r1=6.0, B0=1.0 T
A substance under development (preclin.) as an intravascular MRI contrast agent for MR angiography and capillary permeability detection.

(B) Also called magnetic flux density with the SI unit tesla (T) usually denoted by the symbol B. The magnetic induction is the net magnetic effect from an externally applied magnetic field and the resulting magnetization.
The symbol H was used for the magnetic field (measured in amperes per meter (A/m)). However, this distinction is often ignored, and both quantities are often referred to as the magnetic field.
B is proportional to H (B = μH).
(μ is the magnetic permeability (in henries per meter) of the medium)

Paramagnetic materials attract and repel like normal magnets when subject to a magnetic field. This alignment of the atomic dipoles with the magnetic field tends to strengthen it, and is described by a relative magnetic permeability greater than unity. Paramagnetism requires that the atoms individually have permanent dipole moments even without an applied field, which typically implies a partially filled electron shell. In pure Paramagnetism (without an external magnetic field), these atomic dipoles do not interact with one another and are randomly oriented in the absence of an external field, resulting in zero net moment.
Paramagnetic materials in magnetic fields will act like magnets but when the field is removed, thermal motion will quickly disrupt the magnetic alignment. In general, paramagnetic effects are small (magnetic susceptibility of the order of 10^-3 to 10^-5).
In MRI, gadolinium (Gd) one of these paramagnetic materials is used as a contrast agent. Through interactions between the electron spins of the paramagnetic gadolinium and the water nuclei nearby, the relaxation rates (T1 and T2) of the water protons are increased (T1 and T2 times are decreased), causing an increase in signal on T1 weighted images.

See also contrast agents, magnetism, ferromagnetism, superparamagnetism, and diamagnetism.

Magnetic shielding through the use of high permeability material. The iron provides a return path for the stray field lines of magnetic flux and so significantly decreases the flux away from the magnet.
Passive shielding (see also Faraday cage) significantly eases the problems of siting a MR imager in a confined space. Ferromagnetic objects are less prone to being attracted to the magnet, ancillary electronic equipment, credit cards and computer disks can be brought closer to the magnet and the MRI safety limit for pacemaker wearers (the 5 gauss line = 0.5 mT) is reduced from, typically, 10 m to 2 m from the magnet. A passive shield for a whole-body MRI magnet weights many tons. An alternative method of controlling stray field is active shielding.

See also Active Shielding, Magnetic Shielding, Self Shielding and Room Shielding.