(EPI) Echo planar imaging is one of the early magnetic resonance imaging sequences (also known as Intascan), used in applications like diffusion, perfusion, and functional magnetic resonance imaging. Other sequences acquire one k-space line at each phase encoding step. When the echo planar imaging acquisition strategy is used, the complete image is formed from a single data sample (all k-space lines are measured in one repetition time) of a gradient echo or spin echo sequence (see single shot technique) with an acquisition time of about 20 to 100 ms. The pulse sequence timing diagram illustrates an echo planar imaging sequence from spin echo type with eight echo train pulses. (See also Pulse Sequence Timing Diagram, for a description of the components.)
In case of a gradient echo based EPI sequence the initial part is very similar to a standard gradient echo sequence. By periodically fast reversing the readout or frequency encoding gradient, a train of echoes is generated.
EPI requires higher performance from the MRI scanner like much larger gradient amplitudes. The scan time is dependent on the spatial resolution required, the strength of the applied gradient fields and the time the machine needs to ramp the gradients.
In EPI, there is water fat shift in the phase encoding direction due to phase accumulations. To minimize water fat shift (WFS) in the phase direction fat suppression and a wide bandwidth (BW) are selected. On a typical EPI sequence, there is virtually no time at all for the flat top of the gradient waveform. The problem is solved by "ramp sampling" through most of the rise and fall time to improve image resolution.
The benefits of the fast imaging time are not without cost. EPI is relatively demanding on the scanner hardware, in particular on gradient strengths, gradient switching times, and receiver bandwidth. In addition, EPI is extremely sensitive to image artifacts and distortions.

The use of MR spectroscopy for acquiring functional activation of the brain.
There are two possible approaches:
In the first, localized spectra of brain water are acquired and subtle changes in these spectra reflect the biophysical water environment. Changes in T2 due to deoxyhaemoglobin concentration may be detected in this way. The disadvantages of poor spatial resolution are to some extent offset by the high signal to noise ratio SNR of the spectroscopic data.
An alternative approach is to use MR spectroscopy directly to detect metabolites that are altered by brain activation. These include lactate and glucose. Such experiments have inherently poor spatial and temporal resolution, but do give a direct indication of the metabolic response of the brain to functional activation.

(fMRI) Functional magnetic resonance imaging is a technique used to determine the dynamic brain function, often based on echo planar imaging, but can also be performed by using contrast agents and observing their first pass effects through brain tissue. Functional magnetic resonance imaging allows insights in a dysfunctional brain as well as into the basic workings of the brain.
The in functional brain MRI most frequently used effect to assess brain function is the blood oxygenation level dependent contrast (BOLD) effect, in which differential changes in brain perfusion and their resultant effect on the regional distribution of oxy- to deoxyhaemoglobin are observable because of the different 'intrinsic contrast media' effects of the two haemoglobin forms. Increased brain activity causes an increased demand for oxygen, and the vascular system actually overcompensates for this, increasing the amount of oxygenated haemoglobin. Because deoxygenated haemoglobin attenuates the MR signal, the vascular response leads to a signal increase that is related to the neural activity.
Functional imaging relates body function or thought to specific locations where the neural activity is taking place. The brain is scanned at low resolution but at a fast rate (typically once every 2-3 seconds). Structural MRI together with fMRI provides an anatomical baseline and best spatial resolution.
Interactions can also be seen from the motor cortex to the cerebellum or basal ganglia in the case of a movement disorder such as ataxia. For example: by a finger movement the briefly increase in the blood circulation of the appropriate part of the brain controlling that movement, can be measured.

(HS) A method in which approximately one half of the acquisition matrix in the phase encoding direction is acquired. Half scan is possible because of symmetry in acquired data. Since negative values of phase encoded measurements are identical to corresponding positive values, only a little over half (more than 62.5%) of a scan actually needs to be acquired to replicate an entire scan. This results in a reduction in scan time at the expense of signal to noise ratio. The time reduction can be nearly a factor of two, but full resolution is maintained.
Half scan can be used when scan times are long, the signal to noise ratio is not critical and where full spatial resolution is required. Half scan is particularly appropriate for scans with a large field of view and relatively thick slices; and, in 3D scans with many slices. In some fast scanning techniques the use of Half scan enables a shorter TE thus improving contrast. For this reason, the Half scan parameter is located in the contrast menu.

More information about scan time reduction; see also partial fourier technique.

Inhomogeneity is the degree of lack of homogeneity, for example the fractional deviation of the local magnetic field from the average value of the field. Inhomogeneities of the static magnetic field, produced by the scanner as well as by object susceptibility, is unavoidable in MRI. The large value of gyromagnetic coefficient causes a significant frequency shift even for few parts per million field inhomogeneity, which in turn causes distortions in both geometry and intensity of the MR images.
Manufacturers try to make the magnetic field as homogeneous as possible, especially at the core of the scanner. Even with an ideal magnet, a little inhomogeneity is always left and is caused in addition by the susceptibility of the imaging object. The geometrical distortion (displacement of the pixel locations) are important e.g., for some cases as stereotactic surgery. Displacements up to 3 to 5 mm have been reported. The second problem is the undesired changes in the intensity or brightness of pixels, which may cause problems in determining different tissues and reduce the maximum achievable image resolution.

General strategies for reducing field inhomogeneity induced artifacts:
Increasing the strength of the gradient magnetic field.
Decreasing the echo time.
Improving the image resolution. Phase encoding. Postprocessing.