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The T1 relaxation time (also called spin lattice or longitudinal relaxation time), is a biological parameter that is used in MRIs to distinguish between tissue types. This tissue-specific time constant for protons, is a measure of the time taken to realign with the external magnetic field. The T1 constant will indicate how quickly the spinning nuclei will emit their absorbed RF into the surrounding tissue.
As the high-energy nuclei relax and realign, they emit energy which is recorded to provide information about their environment. The realignment with the magnetic field is termed longitudinal relaxation and the time in milli seconds required for a certain percentage of the tissue nuclei to realign is termed 'Time 1' or T1. Starting from zero magnetization in the z direction, the z magnetization will grow after excitation from zero to a value of about 63% of its final value in a time of T1. This is the basic of T1 weighted images.
The T1 time is a contrast determining tissue parameter. Due to the slow molecular motion of fat nuclei, longitudinal relaxation occurs rather rapidly and longitudinal magnetization is regained quickly. The net magnetic vector realigns with B0 leading to a short T1 time for fat.
Water is not as efficient as fat in T1 recovery due to the high mobility of the water molecules. Water nuclei do not give up their energy to the lattice (surrounding tissue) as quickly as fat, and therefore take longer to regain longitudinal magnetization, resulting in a long T1 time.
See also T1 Weighted Image, T1 Relaxation, T2 Weighted Image, and Magnetic Resonance Imaging MRI. | | | | | | • View the DATABASE results for 'T1 Time' (15).
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Every tissue in the human body has its own T1 and T2 value. This term is used to indicate an image where most of the contrast between tissues is due to differences in the T1 value.
This term may be misleading in that the potentially important effects of tissue density differences and the range of tissue T1 values are ignored.
If the machine parameters are chosen, so that TR less than T1 (typically under 500 ms) and TE less than T2 (typically under 30 ms), a power series expansion of the exponential functions and then neglecting second and higher order terms yields
Mxy = Mxy0 TR/T1
thus the expression becomes independent of T2 and yields the condition for T1 weighting.
Therefore a T1 contrast is approached by imaging with a short TR, compared to the longest tissue T1 of interest and short TE, compared to tissue T2 (to reduce T2 contributions to image contrast). Due to the wide range of T1 and T2 and tissue density values that can be found in the body, an image that is T1 weighted for some tissues may not be so for others.
Lesions with short T1 are (bright in T1 weighted sequences):
fat (lipoma, dermoid)
sub-acute haemorrhage (metHb)
paramagnetic agent (Gd, pituitary)
protein-containing fluid (colloid cyst)
metastatic melanoma (melanotic). | | | | | | • View the DATABASE results for 'T1 Weighted' (56).
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In simple ultrafast GRE imaging, TR and TE are so short, that tissues have a poor imaging signal and - more importantly - poor contrast except when contrast media enhanced ( contrast enhanced angiography). Therefore, the magnetization is 'prepared' during the preparation module, most frequently by an initial 180° inversion pulse.
In the pulse sequence timing diagram, the basic ultrafast gradient echo sequence is illustrated. The 180° inversion pulse is executed one time (to the left of the vertical line), the right side represents the data collection period and is often repeated depending on the acquisition parameters.
See also Pulse Sequence Timing Diagram, there you will find a description of the components.
Ultrafast GRE sequences have a short TR,TE, a low flip angle and TR is so short that image acquisition lasts less than 1 second and typically less than 500 ms. Common TR: 3-5 msec, TE: 2 msec, and the flip angle is about 5°.
Such sequences are often labeled with the prefix 'Turbo' like TurboFLASH, TurboFFE and TurboGRASS.
This allows one to center the subsequent ultrafast GRE data acquisition around the inversion time TI, where one of the tissues of interest has very little signal as its z-magnetization is passing through zero.
Unlike a standard inversion recovery (IR) sequence, all lines or a substantial segment of k-space image lines are acquired after a single inversion pulse, which can then together be considered as readout module. The readout module may use a variable flip angle approach, or the data acquisition may be divided into multiple segments (shots). The latter is useful particularly in cardiac imaging where acquiring all lines in a single segment may take too long relative to the cardiac cycle to provide adequate temporal resolution.
If multiple lines are acquired after a single pulse, the pulse sequence is a type of gradient echo echo planar imaging (EPI) pulse sequence. See also Magnetization Prepared Rapid Gradient Echo ( MPRAGE) and Turbo Field Echo ( TFE). | | | | • View the DATABASE results for 'Ultrafast Gradient Echo Sequence' (13).
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( USPIO) The class of the ultrasmall superparamagnetic iron oxide includes several chemically and pharmacologically very distinct materials, which may or may not be interchangeable for a specific use. Some ultrasmall SPIO particles (median diameter less than 50nm) are used as MRI contrast agents ( Sinerem®, Combidex®), e.g. to differentiate metastatic from inflammatory lymph nodes. USPIO shows also potential for providing important information about angiogenesis in cancer tumors and could possibly complement MRI helping physicians to identify dangerous arteriosclerosis plaques.
Because of the disadvantageous large T2*//T1 ratio, USPIO compounds are less suitable for arterial bolus contrast enhanced magnetic resonance angiography than gadolinium complexes. The tiny ultrasmall superparamagnetic iron oxides do not accumulate in the RES system as fast as larger particles, which results in a long plasma half-life.
USPIO particles, with a small median diameter (less than 10 nm), will accumulate in lymph nodes after an intravenous injection by e.g. direct transcapillary passage through endothelial venules. Once within the nodal parenchyma, phagocytic cells of the mononuclear phagocyte system take up the particles.
As a second way, USPIOs are subsequently taken up from then interstitium by lymphatic vessels and transported to regional lymph nodes. A lymph node with normal phagocytic function takes up a considerable amount and shows a reduction of the signal intensity caused by T2 shortening effects and magnetic susceptibility. Caused by the small uptake of the USPIOs in metastatic lymph nodes, they appear with less signal reduction, and permit the differentiation of healthy lymph nodes from normal-sized, metastatic nodes.
See also Superparamagnetic Contrast Agents, Superparamagnetic Iron Oxide, Very Small Superparamagnetic Iron Oxide Particles, Blood Pool Agents, Intracellular Contrast Agents. | | | | • View the DATABASE results for 'Ultrasmall Superparamagnetic Iron Oxide' (16).
| | | • View the NEWS results for 'Ultrasmall Superparamagnetic Iron Oxide' (2).
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