(LE) Myocardial late enhancement in
contrast enhanced
cardiac MRI has the ability to precisely delineate myocardial scar associated with coronary artery disease. Viability imaging implies evaluating infarcted myocardium to see whether there is enough viable tissue available for revascularization. The reversal of myocardial dysfunction is particularly relevant in patients with depressed ventricular function because revascularization improves long-term survival. In comparison to SPECT and PET imaging, myocardial late enhancement
MRI demonstrates areas of delayed enhancement exactly in correlation with the infarcted region.
Viability on
cardiac MRI (CMR) is based on the fact that all infarcts enhance vividly 10-15 minutes after the administration of intravenous
paramagnetic contrast agents. This enhancement represents the accumulation of
gadolinium in the extracellular space, due to the loss of membrane integrity in the infarcted tissue. This phenomenon of delayed hyperenhancement has been proven to correlate with the actual extent of the infarct.
MRI myocardial late enhancement can quantify the size, location and transmural extent of the infarct. If the transmural extent of the infarct (region of enhancement on
MRI) is less than 50% of the wall thickness, there will be improved contractility in that segment following revascularization. In areas of hypokinesia, if there is a rim of "black" or non-infarcted myocardium that is not contracting well, it indicates the presence of hibernating myocardium, which is likely to improve after revascularization of the artery supplying that particular territory.
The total duration of a myocardial late enhancement
MR imaging protocol for viability is approximately 30 minutes, including scout images, first-pass images,
cine images in two planes, and delayed myocardial enhancement images. In order to assess viable myocardium, the
gadolinium contrast agent is injected at a dose of 0.15 to 0.2 mmol/kg. After about 10 minutes,
short axis and long axis views (see
cardiac axes) of the heart are obtained using an
inversion prepared ECG gated
gradient echo sequence. The
inversion pulse is adjusted to suppress normal myocardium. Areas of nonviable myocardium retain extremely high
signal intensity, black areas show normal tissue.
For Ultrasound Imaging (USI) see
Myocardial Contrast Echocardiography at
Medical-Ultrasound-Imaging.com.