(TOF) The time of flight angiography is used for the imaging of vessels. Usually the sequence type is a gradient echo sequences with short TR, acquired with slices perpendicular to the direction of blood flow.
The source of diverse flow effects is the difference between the unsaturated and presaturated spins and creates a bright vascular image without the invasive use of contrast media. Flowing blood moves unsaturated spins from outside the slice into the imaging plane. These completely relaxed spins have full equilibrium magnetization and produce (when entering the imaging plane) a much higher signal than stationary spins if a gradient echo sequence is generated. This flow related enhancement is also referred to as entry slice phenomenon, or inflow enhancement.
Performing a presaturation slab on one side parallel to the slice can selectively destroy the MR signal from the in-flowing blood from this side of the slice. This allows the technique to be flow direction sensitive and to separate arteriograms or venograms. When the local magnetization of moving blood is selectively altered in a region, e.g. by selective excitation, it carries the altered magnetization with it when it moves, thus tagging the selected region for times on the order of the relaxation times.
For maximum flow signal, a complete new part of blood has to enter the slice every repetition (TR) period, which makes time of flight angiography sensitive to flow-velocity. The choice of TR and slice thickness should be appropriate to the expected flow-velocities because even small changes in slice thickness influences the performance of the TOF sequence. The use of sequential 2 dimensional Fourier transformation (2DFT) slices, 3DFT slabs, or multiple 3D slabs (chunks) are depending on the coverage required and the range of flow-velocities.
3D TOF MRA is routinely used for evaluating the Circle of Willis.

See also Magnetic Resonance Angiography and Contrast Enhanced Magnetic Resonance Angiography.

A technique, which produces a 3 dimensional image of an object. The advantage of this approach is that the signal, acquired from the entire volume has an increased SNR. 'Slices' are defined by a second phase encoded axis, which divides the volume into 'partitions'. There is no gap between the slices in 3D volume imaging, therefore thin slices are possible. The Gz phase encoding gradient is set for several slices in one. But 3D takes more time with thin slices because of this phase encoding gradient. With conventional thin slice imaging, the SNR is poor, with 3D volume imaging this is not the case because the slab (volume) is responsible for SNR.

If available, some graphic aids can be helpful to show image orientations.
1) A graphic icon of the labeled primary axes (A, L, H) with relative lengths given by direction sines and orientation as if viewed from the normal to the image plane can help orient the viewer, both to identify image plane orientation and to indicate possible in plane rotation.
2) Ingraphic prescription of obliques from other images, a sample original image with an overlaid line or set of lines indicating the intersection of the original and oblique image planes can help orient the viewer.
The location in the R/L and P/A directions can be specified relative to the axis of the magnet.
The F/H location can be specified relative to a convenient patient structure.
The orientation of single oblique slices can be specified by rotating a slice in one of the basic orientations toward one of the other two basic orthogonal planes about an axis defined by the intersection of the 2 planes.
Double oblique slices can be specified as the result of tipping a single oblique plane toward the remaining basic orientation plane, about an axis defined by the intersection of the oblique plane and the remaining basic plane. In double oblique angulations, the first rotation is chosen about the vertical image axis and the second about the (new) horizontal axis.
Angles are chosen to have magnitudes less than 90° (for single oblique slices less than 45°); the sign of the angle is taken to be positive when the rotation brings positive axes closer together.

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