Gastrointestinal (GI)
superparamagnetic contrast agents are used in
MRI to improve the visualization of e.g., the intestinal tract, the
pancreas (see
MRCP), etc.
Disadvantages are
susceptibility artifacts e.g., dependent on delayed imaging or large volumes resulting in artifacts in the colon and distal small bowel loops related to higher concentration of the particles and absorption of the fluid.
Di
fferent types of
MRI gastrointestinal superparamagnetic
contrast agents:
•
Magnetite albumin microsphere
Usually gastrointestinal superparamagnetic
contrast media consist of small iron oxide crystals (ferrites), which produce a signal reduction in the stomach and bowel after oral administration. The
T2 shortening caused by these particles is produced from the local
magnetic field inhomogeneities associated with the large magnetic moments of superparamagnetic particles. Ferrites are iron oxides of the general formula Fe203.MO, where M is a divalent metal ion and may be mixed with Fe3O4 in di
fferent preparations.
Ferrites can produce symptoms of nausea after oral administration, as well as flatulence and a transient rise in serum iron. Embedding in inert substances reduce side e
ffects by decreasing the absorption and interaction with body tissues. Combining these
contrast materials with polymers such as polyethylene glycol or cellulose, or with sugars such as dextrose, results in improved
T1 and/or
T2 relaxivity compared with that of the
contrast agent alone.
See also
Negative Oral Contrast Agents,
Gastrointestinal Diamagnetic Contrast Agents,
Relaxivity, and
Combination Oral Contrast Agents.