Ferristene is a superparamagnetic agent that has been used as a magnetic iron particle solution for gastrointestinal use as a negative contrast agent with 23.4 Fe/200ml required concentration.

See also Abdoscan®, Oral Contrast Agents.

Short name: SHU 555 A, generic name: Ferucarbotran
A RES-directed MRI contrast agent (SPIO) made-up of a colloidal sol of iron oxide nanoparticles coated with carboxydextran (Resovist®, Cliavist™).
It is used for the detection and characterization of especially small focal liver lesions and offers the opportunity to make a reliable diagnosis at a very early stage of patients with suspected liver tumors.
Bayer Schering Pharma AG announced that it has received marketing approval for the liver-specific contrast agent Resovist® in Japan. See Contrast Agents and Superparamagnetic Contrast Agents.

Short name: AMI-25, generic name: Ferumoxide (SPIO)
Ferumoxides are superparamagnetic (T2*) MRI contrast agents, so the largest signal change is on T2 and T2* weighted images.
The agent distributes relatively rapidly to organs with reticuloendothelial cells primarily the liver, spleen and bone marrow. The liver shows decreased signal intensity, as does the spleen and marrow. The agent is taken up by the normal liver, resulting in increased CNR between tumor and normal liver. Hepatocellular lesions, such as adenoma or focal nodular hyperplasia, contain reticuloendothelial cells, so they will behave similar to the liver, with decreased signal on T2 weighted images. On T1 images, there is typically some circulating contrast agent, and blood vessels show increased signal intensity.
Current MRI protocols involve T1 weighted breath-hold gradient echo images of the liver, and fast spin echo T2 weighted pictures. This requires about 15 minutes. The patient is then removed from the scanner, and the contrast agent administered. After contrast administration, the same pulse sequences are again repeated.

(GastroMARK®, Lumirem®) A superparamagnetic MRI contrast agent for the gastrointestinal tract.

See also Oral Contrast Agents.

Quick Overview

A disturbance of the field homogeneity, because of magnetic material (inside or outside the patient), technical problems or scanning at the edge of the field.
When images were obtained in a progression from the center to the edge of the coil, the homogeneity of the field observed by the imaged volume, changes when the distance from the center of the volume increase. The same problem appears by scanning at a distance from the isocenter in left-right direction or too large field of view.
There are different types of bad image quality, the images are noisy, distorted or the fat suppression doesn't work because of badly set shim currents.
E.g. by using an IR sequence, changes in the T1 recovery rates of the tissues are involved. The inversion time at the center of the imaged volume is appropriate to suppress fat, but at the edge of the coil the same inversion time is sufficient to suppress water. Since the inversion time is not changed, the T1 recovery rates will increase.

Take a smaller imaging volume (and for fat suppression a volume shimming), take care that the imaged region is at the center of the coil and that no magnetic material is inside the imaging volume.