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MRI Resources 
Contrast Enhanced MRI - Chemistry - Raman Spectroscopy - Intraoperative MRI - Supplies - MRA
 
Inversion Recovery SequenceForum -
related threadsInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.
 
Inversion Recovery Sequence Timing Diagram (IR) The inversion recovery pulse sequence produces signals, which represent the longitudinal magnetization existing after the application of a 180° radio frequency pulse that rotates the magnetization Mz into the negative plane. After an inversion time (TI - time between the starting 180° pulse and the following 90° pulse), a further 90° RF pulse tilts some or all of the z-magnetization into the xy-plane, where the signal is usually rephased with a 180° pulse as in the spin echo sequence. During the initial time period, various tissues relax with their intrinsic T1 relaxation time.
In the pulse sequence timing diagram, the basic inversion recovery sequence is illustrated. The 180° inversion pulse is attached prior to the 90° excitation pulse of a spin echo acquisition. See also the Pulse Sequence Timing Diagram. There you will find a description of the components.
The inversion recovery sequence has the advantage, that it can provide very strong contrast between tissues having different T1 relaxation times or to suppress tissues like fluid or fat. But the disadvantage is, that the additional inversion radio frequency RF pulse makes this sequence less time efficient than the other pulse sequences.

Contrast values:
PD weighted: TE: 10-20 ms, TR: 2000 ms, TI: 1800 ms
T1 weighted: TE: 10-20 ms, TR: 2000 ms, TI: 400-800 ms
T2 weighted: TE: 70 ms, TR: 2000 ms, TI: 400-800 ms

See also Inversion Recovery, Short T1 Inversion Recovery, Fluid Attenuation Inversion Recovery, and Acronyms for 'Inversion Recovery Sequence' from different manufacturers.
 
Images, Movies, Sliders:
 Brain MRI Inversion Recovery  Open this link in a new window
    
 Knee MRI Sagittal STIR 002  Open this link in a new window
 Brain MRI Coronal FLAIR 001  Open this link in a new window
    
 
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• Related Searches:
    • Saturation Pulses
    • Knee MRI
    • Flow Sensitive Alternating Inversion Recovery
    • Short T1 Inversion Recovery
    • Brain MRI
 
Further Reading:
  Basics:
The equation for a repeated inversion recovery sequence
Contrast mechanisms in magnetic resonance imaging
2004   by www.iop.org    
  News & More:
FLAIR Vascular Hyperintensity: An Important MRI Marker in Patients with Transient Ischemic Attack
Thursday, 14 July 2022   by www.dovepress.com    
MRI Resources 
Quality Advice - Devices - DICOM - Claustrophobia - Lung Imaging - Distributors
 
Contrast Enhanced MRIInfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Enhanced MRI -
 
Contrast enhanced MRI is a commonly used procedure in magnetic resonance imaging. The need to more accurately characterize different types of lesions and to detect all malignant lesions is the main reason for the use of intravenous contrast agents.
Some methods are available to improve the contrast of different tissues. The focus of dynamic contrast enhanced MRI (DCE-MRI) is on contrast kinetics with demands for spatial resolution dependent on the application. DCE-MR imaging is used for diagnosis of cancer (see also liver imaging, abdominal imaging, breast MRI, dynamic scanning) as well as for diagnosis of cardiac infarction (see perfusion imaging, cardiac MRI). Quantitative DCE-MRI requires special data acquisition techniques and analysis software.
Contrast enhanced magnetic resonance angiography (CE-MRA) allows the visualization of vessels and the temporal resolution provides a separation of arteries and veins. These methods share the need for acquisition methods with high temporal and spatial resolution.
Double contrast administration (combined contrast enhanced (CCE) MRI) uses two contrast agents with complementary mechanisms e.g., superparamagnetic iron oxide to darken the background liver and gadolinium to brighten the vessels. A variety of different categories of contrast agents are currently available for clinical use.
Reasons for the use of contrast agents in MRI scans are:
Relaxation characteristics of normal and pathologic tissues are not always different enough to produce obvious differences in signal intensity.
Pathology that is sometimes occult on unenhanced images becomes obvious in the presence of contrast.
Enhancement significantly increases MRI sensitivity.
In addition to improving delineation between normal and abnormal tissues, the pattern of contrast enhancement can improve diagnostic specificity by facilitating characterization of the lesion(s) in question.
Contrast can yield physiologic and functional information in addition to lesion delineation.
Imaging of arteries and veins with contrast enhanced angiography (CE MRA).

Common Indications:
Brain MRI : Preoperative/pretreatment evaluation and postoperative evaluation of brain tumor therapy, CNS infections, noninfectious inflammatory disease and meningeal disease.
Spine MRI : Infection/inflammatory disease, primary tumors, drop metastases, initial evaluation of syrinx, postoperative evaluation of the lumbar spine: disk vs. scar.
Breast MRI : Detection of breast cancer in case of dense breasts, implants, malignant lymph nodes, or scarring after treatment for breast cancer, diagnosis of a suspicious breast lesion in order to avoid biopsy.

For Ultrasound Imaging (USI) see Contrast Enhanced Ultrasound at Medical-Ultrasound-Imaging.com. See also Blood Pool Agents, Myocardial Late Enhancement, Cardiovascular Imaging, Contrast Enhanced MR Venography, Contrast Resolution, Dynamic Scanning, Lung Imaging, Hepatobiliary Contrast Agents, Contrast Medium and MRI Guided Biopsy.
 
Images, Movies, Sliders:
 Delayed Myocardial Contrast Enhancement from Infarct  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 Left Circumflex Ischemia First-pass Contrast Enhancement  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 Normal Lung Gd Perfusion MRI  Open this link in a new window
 MRI of the Brain Stem with Temoral Bone and Auditory System  Open this link in a new window
    
SlidersSliders Overview

 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
 
Radiology-tip.comradContrast Enhanced Computed Tomography
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Medical-Ultrasound-Imaging.comContrast Enhanced Ultrasound,  Contrast Enhanced Doppler Imaging
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• View the DATABASE results for 'Contrast Enhanced MRI' (14).Open this link in a new window


• View the NEWS results for 'Contrast Enhanced MRI' (8).Open this link in a new window.
 
Further Reading:
  Basics:
Optimal k-Space Sampling for Dynamic Contrast-Enhanced MRI with an Application to MR Renography
Thursday, 5 November 2009   by www.ncbi.nlm.nih.gov    
  News & More:
FDA Approves Gadopiclenol for Contrast-Enhanced Magnetic Resonance Imaging
Tuesday, 27 September 2022   by www.pharmacytimes.com    
Effect of gadolinium-based contrast agent on breast diffusion-tensor imaging
Thursday, 6 August 2020   by www.eurekalert.org    
Artificial Intelligence Processes Provide Solutions to Gadolinium Retention Concerns
Thursday, 30 January 2020   by www.itnonline.com    
Accuracy of Unenhanced MRI in the Detection of New Brain Lesions in Multiple Sclerosis
Tuesday, 12 March 2019   by pubs.rsna.org    
The Effects of Breathing Motion on DCE-MRI Images: Phantom Studies Simulating Respiratory Motion to Compare CAIPIRINHA-VIBE, Radial-VIBE, and Conventional VIBE
Tuesday, 7 February 2017   by www.kjronline.org    
Novel Imaging Technique Improves Prostate Cancer Detection
Tuesday, 6 January 2015   by health.ucsd.edu    
New oxygen-enhanced MRI scan 'helps identify most dangerous tumours'
Thursday, 10 December 2015   by www.dailymail.co.uk    
All-organic MRI Contrast Agent Tested In Mice
Monday, 24 September 2012   by cen.acs.org    
A groundbreaking new graphene-based MRI contrast agent
Friday, 8 June 2012   by www.nanowerk.com    
MRI Resources 
IR - Artifacts - Quality Advice - Pathology - Process Analysis - Functional MRI
 
Lung ImagingMRI Resource Directory:
 - Lung Imaging -
 
Lung imaging is furthermore a challenge in MRI because of the predominance of air within the lungs and associated susceptibility issues as well as low signal to noise of the inflated lung parenchyma. Cardiac and respiratory triggered or breath hold sequences allow diagnostic imaging, however a comparable image quality with computed tomography is still difficult to achieve.
Assumptions for lung MRI:
•
Low signal to noise ratio of the inherently low lung proton density.
•
Cardiac and respiratory motion artifacts.
•
Magnetic susceptibility effects of large magnetic field gradients.
•
Very short transverse relaxation times and significant diffusion yielding short T2 (30-70 msec), short T2* (1-3 msec), and additional long T1 relaxation times (1300-1500 msec).
•
The extreme short T2 values are responsible for a fast signal decay during a single shot readout, resulting in blurring.

The current trends in MRI are the use of new imaging technologies and increasingly powerful magnetic fields. Among these technologies are parallel imaging techniques as well as ventilation agents like hyperpolarized helium for the use as an inert inhalational contrast agent to study lung ventilation properties. With hyperpolarized gases clear images of the lungs can be obtained without using a large magnetic field (see also back projection imaging). Single shot sequences (e.g. TSE or Half Fourier Acquisition Single Shot Turbo Spin Echo HASTE) used in lung MR imaging benefits from parallel imaging techniques due to reduced relaxation time effects during the echo train and therefore reduced image blurring as well as reduced motion artifacts.
In the future, more effective contrast agents may provide an alternative solution to the need for high field MRI. Dynamic contrast enhanced MRI perfusion has demonstrated a potential in the diagnosis of pulmonary embolism or to characterize lung cancer and mediastinal tumors. 3D contrast enhanced magnetic resonance angiography of the thoracic vessel.

See also the related poll result: 'MRI will have replaced 50% of x-ray exams by'
 
Images, Movies, Sliders:
 Anatomic Imaging of the Lungs  Open this link in a new window
      

Courtesy of  Robert R. Edelman
 Normal Lung Gd Perfusion MRI  Open this link in a new window
      

Courtesy of  Robert R. Edelman

 MRI Thorax Basal Plane  Open this link in a new window
 
Radiology-tip.comradLung Scintigraphy
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• View the DATABASE results for 'Lung Imaging' (7).Open this link in a new window


• View the NEWS results for 'Lung Imaging' (3).Open this link in a new window.
 
Further Reading:
  Basics:
A safer approach for diagnostic medical imaging
Monday, 29 September 2014   by www.eurekalert.org    
Parallel Lung Imaging(.pdf)
  News & More:
Chest MRI a viable alternative to chest CT in COVID-19 pneumonia follow-up
Monday, 21 September 2020   by www.healthimaging.com    
CT Imaging Features of 2019 Novel Corona virus (2019-nCoV)
Tuesday, 4 February 2020   by pubs.rsna.org    
Polarean Imaging Phase III Trial Results Point to Potential Improvements in Lung Imaging
Wednesday, 29 January 2020   by www.diagnosticimaging.com    
Low Power MRI Helps Image Lungs, Brings Costs Down
Thursday, 10 October 2019   by www.medgadget.com    
Chest MRI Using Multivane-XD, a Novel T2-Weighted Free Breathing MR Sequence
Thursday, 11 July 2019   by www.sciencedirect.co    
Researchers Review Importance of Non-Invasive Imaging in Diagnosis and Management of PAH
Wednesday, 11 March 2015   by lungdiseasenews.com    
New MRI Approach Reveals Bronchiectasis' Key Features Within the Lung
Thursday, 13 November 2014   by lungdiseasenews.com    
MRI techniques improve pulmonary embolism detection
Monday, 19 March 2012   by medicalxpress.com    
  News & More:
Partnership with VIDA to streamline adoption of advanced MRI of the lungs
Monday, 11 September 2023   by www.itnonline.com    
MRI Resources 
MRI Centers - Process Analysis - Developers - MRI Reimbursement - Blood Flow Imaging - Portals
 
Adiabatic Fast Passage
 
(AFP) Adiabatic fast passage is a NMR technique of producing rotation of the macroscopic magnetization vector by shifting the frequency of RF energy pulses (or the strength of the magnetic field) through resonance (the Larmor frequency) in a time short compared to the relaxation times. Particularly used for inversion of the spins between high and low energy states with an excess of spins in the higher energy level. A continuous wave NMR technique used in e.g., MR spectroscopy.
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• View the DATABASE results for 'Adiabatic Fast Passage' (3).Open this link in a new window

 
Further Reading:
  Basics:
Adiabatic theorem
   by en.wikipedia.org    
  News & More:
New theory of adiabaticity developed
Tuesday, 2 December 2008   by www.upi.com    
MRI Resources 
Stent - Non-English - Liver Imaging - Education - MR Guided Interventions - Safety Products
 
Balanced Fast Field EchoInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - Sequences -
 
(bFFE) A FFE sequence using a balanced gradient waveform. A balanced sequence starts out with a RF pulse of 90° or less and the spins in the steady state. Before the next TR in the slice phase and frequency encoding, gradients are balanced so their net value is zero. Now the spins are prepared to accept the next RF pulse, and their corresponding signal can become part of the new transverse magnetization. Since the balanced gradients maintain the transverse and longitudinal magnetization, the result is, that both T1 and T2 contrast are represented in the image. This pulse sequence produces images with increased signal from fluid, along with retaining T1 weighted tissue contrast. Because this form of sequence is extremely dependent on field homogeneity, it is essential to run a shimming prior the acquisition. A fully balanced (refocused) sequence would yield higher signal, especially for tissues with long T2 relaxation times.

See Steady State Free Precession and Gradient Echo Sequence.
 
Images, Movies, Sliders:
 Cardiac Infarct Short Axis Cine bFFE 1  Open this link in a new window
    
 
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• View the DATABASE results for 'Balanced Fast Field Echo' (3).Open this link in a new window

 
Further Reading:
  News & More:
T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI
Monday, 1 September 2008   by www.ncbi.nlm.nih.gov    
Utility of the FIESTA Pulse Sequence in Body Oncologic Imaging: Review
June 2009   by www.ajronline.org    
MRI Resources 
Hospitals - Claustrophobia - Brain MRI - Spine MRI - PACS - Patient Information
 
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