After RF excitation the spins will tend to return to their equilibrium distribution in which there is no transverse magnetization and the longitudinal magnetization is at its maximum value and oriented in the direction of the static magnetic field. The transverse magnetization decays toward zero with a characteristic time constant T2, and the longitudinal magnetization returns toward equilibrium with a characteristic time constant T1.

Contrast is the relative difference of signal intensities in two adjacent regions of an image.
Due to the T1 and T2 relaxation properties in magnetic resonance imaging, differentiation between various tissues in the body is possible. Tissue contrast is affected by not only the T1 and T2 values of specific tissues, but also the differences in the magnetic field strength, temperature changes, and many other factors. Good tissue contrast relies on optimal selection of appropriate pulse sequences (spin echo, inversion recovery, gradient echo, turbo sequences and slice profile).
Important pulse sequence parameters are TR (repetition time), TE (time to echo or echo time), TI (time for inversion or inversion time) and flip angle. They are associated with such parameters as proton density and T1 or T2 relaxation times. The values of these parameters are influenced differently by different tissues and by healthy and diseased sections of the same tissue.
For the T1 weighting it is important to select a correct TR or TI. T2 weighted images depend on a correct choice of the TE. Tissues vary in their T1 and T2 times, which are manipulated in MRI by selection of TR, TI, and TE, respectively. Flip angles mainly affect the strength of the signal measured, but also affect the TR/TI/TE parameters.
Conditions necessary to produce different weighted images:
T1 Weighted Image: TR value equal or less than the tissue specific T1 time - TE value less than the tissue specific T2 time.
T2 Weighted Image: TR value much greater than the tissue specific T1 time - TE value greater or equal than the tissue specific T2 time.
Proton Density Weighted Image: TR value much greater than the tissue specific T1 time - TE value less than the tissue specific T2 time.

See also Image Contrast Characteristics, Contrast Reversal, Contrast Resolution, and Contrast to Noise Ratio.

Diffusion weighted imaging can be performed similar to the phase contrast angiography sequence. The gradients must be increased in amplitude to depict the much slower motions of molecular diffusion in the body.
While a T1 weighted MRI pulse sequence is diffusion sensitive, a quantitative diffusion pulse sequence was introduced by Steijskal and Tanner. Its characteristic features are two strong symmetrical gradient lobes placed on either side of the 180° refocusing pulse in a spin echo sequence. These symmetrical gradient lobes have the sole purpose of enhancing dephasing of spins, thereby accelerating intravoxel incoherent motion (IVIM) signal loss.
Dephasing is proportional to the square of the time (diffusion time) during which the gradients are switched on and the strength of the applied gradient field. Therefore, the use of high field gradient systems with faster and more sensitive sequences, make diffusion weighting more feasible.
Areas in which the protons diffuse rapidly (swollen cells in early stroke, less restriction to diffusion) will show an increased signal when the echo is measured relative to areas in which diffusion is restricted. For increased accuracy of diffusion measurement and image enhancement, useful motion correction techniques such as navigator echo and other methods should be used. In addition to this, applying the b-value calculated by the strength and duration of motion probing gradients with a high rate of accuracy is very important.

See also Apparent Diffusion Coefficient, ADC Map, Lattice Index Map.

MR imaging technique in which the spin echo is used rather than the FID. The proper selection of the echo and repetition time of the pulse sequence can help to control the amount of T1 or T2 contrast present in the image. Spin echo imaging can be used to create images that depend strongly on T2 if TE has a value on the order of or greater than T2 of the relevant image details. The spin echoes can be produced as a train of multiple echoes, e.g. using the CPMG pulse sequence.

See also Spin Echo Sequence.

Often used to indicate an image where most of the contrast between tissues or tissue states is due to differences in tissue T2 created typically by using longer TE and TR times.
This term may be misleading in that the potentially important effects of tissue density differences and the range of tissue T2 values are often ignored.
Choosing the machine parameters such that TR greater than T1 (typically greater than 2 000 ms) and TE less than T2 (typically greater than 100 ms) and noting that (1-exp(-TR/T1) = 1 for TR/T1 much greater than 1, will reduce Eq. 1 to the expression
Mxy = Mxy0exp(-TE/T2)
which is dependent on T2 only, hence the term T2 weighting. Therefore T2 weighted image contrast state is approached by imaging with a TR long compared to tissue T1 (to reduce T1 contribution to image contrast) and a TE between the longest and shortest tissue T2s of interest. A TR greater than 3 times the longest T1 is required for the T1 effect to be less than 5%. Due to the wide range of T1 and T2 and tissue density values that can be found in the body, an image that is T2 weighted for some tissues may not be so for others.
See also T2 Time.
Lesions with short T2 are (dark in T2 weighted sequences):
acute haemorrhage (deoxyHb)
haemosiderin
physiologic iron (basal ganglia, etc.)
mucinous lesions.