Lantheus Medical Imaging is a worldwide leader in medical imaging, with headquarters in North Billerica, Massachusetts, and nearly 700 employees worldwide with offices in Puerto Rico, Canada, and Australia.
The product portfolio includes ABLAVAR™ (gadofosveset trisodium) a blood pool contrast agent for magnetic resonance angiography MRA, Cardiolite® (Kit for the preparation of Technetium Tc99m Sestamibi), a cardiac perfusion imaging agent and DEFINITY® Vial for (Perflutren Lipid Microsphere) injectable suspension, the leading cardiac ultrasound contrast agent in the US.

MRI Contrast Agents:

The Larmor equation is important because it is the frequency at which the nucleus will absorb energy. The absorption of that energy will cause the proton to alter its alignment and ranges from 1-100 MHz in MRI. The equation states that the frequency of precession of the nuclear magnetic moment is directly proportional to the product of the magnetic field strength (B0) and the gyromagnetic ratio (g). This is stated mathematically as w = g B0.

The Larmor precession frequency is the rate of precession of a spin packet under the influence of a magnetic field. The frequency of an RF signal, which will cause a change in the nucleus spin energy level, is given by the Larmor equation. The frequency is determined by the gyro magnetic ratio of atoms and the strength of the magnetic field. The gyromagnetic ratio is different for each nucleus of different atoms.
The stronger the magnetic field, the higher the precessional frequency. If an RF pulse at the Larmor frequency is applied to the nucleus of an atom, the protons will alter their alignment from the direction of the main magnetic field to the direction opposite the main magnetic field. As the proton tries to realign with the main magnetic field, it will emit energy at the Larmor frequency. By varying the magnetic field across the body with a magnetic field gradient, the corresponding variation of the Larmor frequency can be used to encode the position. For protons (hydrogen nuclei), the Larmor frequency is 42.58 MHz/Tesla.

See also Larmor Equation.

(LITT) Laser induced thermo therapy is a therapeutically destruction of tumor or metastasis tissue with a thermolaser. Malignant tissue reacts very sensitive to heat. The heating of the malignant tissue results in a degeneration or coagulation and the death of the malignant cells by temperatures from 45 °C to 99 °C.
Induced thermal damage can be variable and unpredictable due to thermally induced changes in tissue thermal and blood perfusion. The affection can be controlled by thermo sensitive MRI sequences. The temperature can be monitored during the procedure and MR imaging following the procedure shows how effectively the tumor is damaged.

In MRI, the magnetic and thermal environment through that nuclei exchange energy in longitudinal (T1) relaxation.